cobrapy

Quick Review

Exceptional skill for constraint-based metabolic modeling. The description is comprehensive and actionable, enabling a CLI agent to invoke all major COBRApy capabilities (FBA, FVA, knockouts, sampling, gapfilling, model I/O). Task knowledge is thorough with complete code examples covering the full analysis pipeline from model loading to advanced workflows. Structure is excellent: SKILL.md provides a well-organized overview with clear sections and references supplementary workflow files appropriately. Novelty is strong—metabolic modeling requires specialized domain knowledge, complex multi-step workflows, and heavy computation that would be expensive for a CLI agent to replicate from scratch. The skill meaningfully reduces token costs for systems biology tasks. Minor point: while structure is very good, a few sections (like Model Building) are quite detailed and could potentially be extracted to references, though this is a minimal concern given the overall clarity.