pysam

Quick Review

Excellent bioinformatics skill for genomic file processing. The description clearly communicates capabilities (SAM/BAM/CRAM, VCF/BCF, FASTA/FASTQ operations) sufficient for CLI invocation. Task knowledge is comprehensive with well-organized core capabilities, code examples, and detailed references for alignment, variant, and sequence file operations. Structure is exemplary: concise SKILL.md overview with clear indexing to detailed reference documents, avoiding clutter while providing depth. Novelty is strong—genomic file processing requires domain-specific knowledge of coordinate systems, indexing requirements, and bioinformatics workflows that would consume many tokens if handled ad-hoc. The skill meaningfully reduces cost for NGS data analysis tasks. Minor improvement possible: description could explicitly mention 'pileup analysis' or 'tabix' for even more precise invocation cues, but current coverage is already very strong.